Creative Biogene Enhances Production of Premium Cosmetic-Grade Ergothioneine

Creative Biogene, an international biotechnology company, announced that it has optimized a microbial production platform for cosmetic-grade Ergothioneine (EGT) of high purity, excellent stability, and sustainable supply. The final product form can be customized according to the formulation needs of cosmetics.

Ergothioneine is a sulfur-containing histidine derivative that was discovered in 1909. Ergothioneine is only naturally produced by some fungi and bacteria, such as Neurospora crassa and Mycobacterium smegmatis. Ergothioneine is a highly potent and stable natural antioxidant, with the ability to scavenge ROS and chelate divalent metal ions (Fe2+, Cu2+) in biological systems, thereby protecting cells against oxidative stress.

Creative Biogene used microbial biologics fermentation technology and metabolic pathway engineering to produce cosmetic-grade Ergothioneine with purity ≥98%, which can be used directly in skincare products to meet quality standards, and provides cosmetics brands with a scalable production platform for premium, efficacy-backed, and sustainable ingredients for skin care products.

“Ergothioneine is a multifunctional ingredient, well-known for its antioxidant capabilities,” the chief scientist of Creative Biogene added. ”It is also an effective multifunctional cosmetic ingredient.”

Uses of Cosmetic-Grade Ergothioneine:

l Antioxidant: Used in anti-oxidative stress formulations caused by the environment.

l Anti-inflammatory: Used in calming and soothing products.

l Anti-aging: Used in skincare products to help overall skin condition and appearance.

l Metal-chelating: Used as a metal ion chelator in products.

In addition to cosmetics applications, Ergothioneine can also be applied in food and biotechnology.

Creative Biogene also provides efficacy evaluation services for Ergothioneine, including in vitro efficacy evaluation using a human skin tissue model to assess hydration, skin barrier, anti-inflammatory and antioxidation properties as well as ex vivo penetration testing using human skin samples. This allows cosmetic brands to ensure a strong development pipeline and meet regulatory requirements.

About Creative Biogene

Creative Biogene provides integrated biotechnology services including strain development, fermentation optimization, downstream purification, analytical testing, and GMP-compliant manufacturing. With its optimized Ergothioneine production technology, Creative Biogene aims to help the cosmetics industry deliver innovative, effective, and sustainable products to improve consumers’ lives.

Accelerating Microbial Innovation with MicrobioSci by Creative Biogene

In the dynamic field of microbial biotechnology, precision, innovation, and reliability are essential to driving scientific discovery and industrial success. MicrobioSci, a dedicated division of Creative Biogene, offers a comprehensive range of microbial services and products tailored to meet the evolving needs of academic institutions, biotech companies, and pharmaceutical enterprises. With advanced capabilities and a commitment to quality, MicrobioSci serves as a trusted partner in microbial research and development.

One of the key services provided by MicrobioSci is Recombinant Vaccine Production. In response to the growing global demand for safer and more effective vaccines, the platform offers end-to-end solutions for the development of recombinant vaccines using various microbial expression systems. This includes gene synthesis, vector construction, expression optimization, protein purification, and scale-up production. The service is designed to accelerate time-to-market while ensuring high yield, purity, and biological activity of the recombinant antigens.

Alongside vaccine development, maintaining consistency and safety in microbial processes is critical. That is why MicrobioSci has developed a rigorous Fermentation Quality Control System. This system monitors critical process parameters such as pH, temperature, dissolved oxygen, and biomass in real time, ensuring reproducibility across fermentation batches. It enables researchers and manufacturers to achieve optimal fermentation performance while meeting regulatory requirements.

To support large-scale and reproducible production, MicrobioSci offers high-quality E. coli Cell Banking services. These services provide clients with well-characterized, genetically stable E. coli strains preserved under stringent conditions. The availability of standardized E. coli cell banks plays a crucial role in reducing variability in protein expression and enhancing the scalability of production processes.

Another unique feature of MicrobioSci’s offerings lies in its supply of specialized enzymes for advanced research. The Trichoderma harzianum Lysing Enzymes, for example, are widely used for degrading fungal cell walls, isolating protoplasts, and supporting a variety of plant pathology and molecular biology studies. These enzymes are carefully produced and quality-tested to ensure superior activity and reliability in experimental applications.

For researchers working with yeast, MicrobioSci provides a professional Yeast Genome Editing Service. Utilizing state-of-the-art genome engineering technologies such as CRISPR/Cas9, this service allows for precise modification of the yeast genome, including gene knockout, gene integration, and promoter replacement. Whether used in synthetic biology, metabolic engineering, or industrial fermentation, this genome editing service supports efficient strain optimization and functional analysis.

In addition, MicrobioSci has become a leading provider of resources for Bacillus research. The platform offers a diverse collection of Bacillus subtilis 168 Knockout Strains, which are valuable tools for functional genomics, metabolic pathway analysis, and drug target identification. These strains are developed using precise gene editing techniques and are fully validated for downstream applications.

Furthermore, MicrobioSci offers custom Bacillus subtilis Strain Development services. Researchers can request strain modifications for improved enzyme production, stress tolerance, biosynthetic capabilities, or other desired traits. Each project is carried out with strict quality control and technical support to ensure the engineered strains meet specific research or production goals.

With a focus on innovation and scientific excellence, MicrobioSci by Creative Biogene continues to provide integrated solutions that advance microbial research and industrial biotechnology. From recombinant vaccine production and quality-controlled fermentation systems to specialized microbial strains and genome editing tools, MicrobioSci is committed to supporting progress across multiple sectors of life science.

For more information about these services, visit MicrobioSci at Creative Biogene.